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Afro Moses capsules contains Penianthus zenkeri and Capparis erythrocarpus both African tropical plant whose roots and leaves are used in traditional medicine for many purposes, especially for erectile dysfunction. Afro Moses capsules extracts contains the following Phytochemicals: Glycosides, Saponins, Tannins, Alkaloids and Flavonoids which are highly antioxidative and induce a slight transcriptional activity of peroxisome proliferator activated receptor-alpha. They also increased and decreased endothelial nitric oxide synthase and endothelin-1 mRNA levels in bovine and aortic endothelial cells, respectively. It could be suggested that the arterial relaxation induced by extracts could be mainly linked to their capacities to inhibit nitric oxide oxidation through their antioxidant properties and this leads to gushing of blood into the Cavernosal sinuses in the Penis enhancing sustained erection for satisfactory sexual performance.